Armodafinil

What Is Armodafinil?

The active enantiomer of the drug modafinil is armodafinil. It is a prescription drug that helps adults who are excessively sleepy due to narcolepsy, obstructive sleep apnea, or shift work sleep disorder stay awake. Armodafinil is a member of the eugeroics, or wakefulness-promoting agents, pharmacological class.

Dopamine and norepinephrine reuptake in the brain is hypothesised to be inhibited by armodafinil, increasing the amount of these neurotransmitters accessible for transmission between neurons. As a result, the brain’s wakefulness-regulating areas become more active, which enhances alertness and attentiveness.

Tablets of armodafinil are offered under the trade name Nuvigil. It is typically taken orally once day in the morning. The dosage of armodafinil is determined by the person’s health status and treatment response.

Armodafinil Dosage

Armodafinil dosage recommendations are based on a person’s health status and how they react to treatment. Armodafinil is often started at a dose of 150 mg once day in the morning for narcolepsy. Depending on the person’s response and tolerance, the dosage may be adjusted to a maximum of 250 mg once daily.

The suggested dose of armodafinil for obstructive sleep apnea is 150 mg once day in the morning. Depending on the person’s response and tolerance, the dosage may be adjusted to a maximum of 250 mg once daily.

The suggested dose of armodafinil for shift work sleep disorder is 150 mg one hour before the start of the work shift.

It’s crucial to adhere to the dosage guidelines given by a healthcare professional and refrain from taking more or less armodafinil than advised. Armodafinil can have negative side effects if taken in excess, but if taken insufficiently, it may not improve wakefulness.

How Does Armodafinil Work?

The active enantiomer of the drug modafinil is armodafinil. It is a prescription drug that helps adults who are excessively sleepy due to narcolepsy, obstructive sleep apnea, or shift work sleep disorder stay awake. Armodafinil is a member of the eugeroics, or wakefulness-promoting agents, pharmacological class.

Although the precise mode of action of armodafinil is not entirely understood, it is believed to operate by preventing dopamine and norepinephrine from reabsorbing in the brain. Neurotransmitters that control wakefulness and attention include dopamine and norepinephrine. Armodafinil raises the levels of dopamine and norepinephrine available for transmission between neurons by reducing their reuptake, which increases the activity of brain areas involved in the control of wakefulness.

Improved alertness and concentration are the outcomes of this heightened activation, which may also have a stimulating impact on the body’s central nervous system. Armodafinil may affect the levels of neurotransmitters as well as other brain chemicals like orexin and histamine, which could add to its effects on boosting alertness.

Armodafinil Pharmacodynamics

The term “armodafinil pharmacodynamics” describes how the drug interacts with the body to increase wakefulness. As was already noted, armodafinil is hypothesised to function by preventing dopamine and norepinephrine from being taken up again in the brain, increasing the amount of these neurotransmitters that are accessible for transmission between neurons. As a result, the brain’s wakefulness-regulating areas become more active, which enhances alertness and attentiveness.

Armodafinil may affect the levels of neurotransmitters as well as other brain chemicals like orexin and histamine, which could add to its effects on boosting alertness. Armodafinil may also stimulate the central nervous system of the body, which could increase alertness and lessen weariness.

It is significant to remember that further study is required to properly understand the pharmacodynamics of armodafinil in order to improve wakefulness.

Armodafinil Pharmacokinetics

Pharmacokinetics of armodafinil describes how the drug is absorbed, distributed, metabolised, and excreted by the body. Armodafinil is processed in the liver when taken orally since it is absorbed from the gastrointestinal system. Armodafinil is primarily excreted from the body through urine.

It takes roughly 15 hours for the concentration of armodafinil in the body to decrease by half, according to the half-life of armodafinil. Armodafinil can be taken once daily and still function effectively throughout the day thanks to its lengthy half-life.


It is crucial to remember that a number of variables, including age, gender, liver function, and the presence of other drugs, may have an impact on the pharmacokinetics of armodafinil.

Armodafinil Side Effects

Armodafinil’s adverse effects are typically divided into the following categories: extremely common (affects more than one in ten people), common (affects one in ten people in a hundred), uncommon (affects one in ten people in a thousand), rare (affects one in ten people in ten thousand), and very rare (affects less than 1 in 10,000 people).

The full list of side effects of armodafinil is provided below, along with how frequently each one occurs:

Extremely prevalent (affects more than one in ten people):

  • Headache
  • Dizziness
  • Nausea
  • Nervousness

Common (affects 1 to 10 in 100 people):

  • Dry mouth
  • Back pain
  • Diarrhea
  • Insomnia

Uncommon (affects 1 to 10 in 1,000 people):

  • Chest pain
  • Difficulty breathing
  • Rash
  • Hives
  • Swelling of the face, lips, tongue, or throat

Rare (affects 1 to 10 in 10,000 people):

  • Rapid or irregular
  • heartbeat
  • High blood pressure
  • Tremor
  • Agitation
  • Confusion
  • Hallucinations

Very rare (affects less than 1 in 10,000 people):

  • Skin rash with blistering or peeling skin
  • Stevens-Johnson syndrome (a serious and potentially life-threatening skin reaction)

If you experience any side effects while taking armodafinil, it is important to speak with a healthcare provider.

Armodafinil Addiction

If armodafinil is abused or used in ways not recommended by a healthcare professional, it is potential for someone to become physically or psychologically dependent on it. Armodafinil dependence can result in withdrawal symptoms if the medicine is withdrawn or the dosage is lowered.

Armodafinil withdrawal effects can include extreme drowsiness, exhaustion, irritability, melancholy, and trouble concentrating. After discontinuing armodafinil, these symptoms could start to appear a few days later and linger for a few weeks.

It is crucial to consult a healthcare professional if you are using armodafinil and want to stop taking it or reduce your dosage. Your doctor can assist you in gradually lowering the dosage of armodafinil so as to reduce the possibility of withdrawal symptoms.

Armodafinil Withdrawal

Like all medications, it is possible for a person to develop physical or psychological dependence on armodafinil if it is misused or taken in ways other than directed by a healthcare provider. Dependence on armodafinil may lead to withdrawal symptoms when the medication is stopped or the dosage is decreased.

The symptoms of armodafinil withdrawal may include excessive sleepiness, fatigue, irritability, depression, and difficulty concentrating. These symptoms may occur within a few days of stopping armodafinil and may last for several weeks.

If you are taking armodafinil and wish to stop or decrease the dosage, it is important to speak with a healthcare provider. Your healthcare provider can help you gradually decrease the dosage of armodafinil in a way that minimizes the risk of withdrawal symptoms.

Armodafinil vs Modafinil?

Both the prescription drugs armodafinil and modafinil are used to increase wakefulness in adults who are excessively sleepy as a result of narcolepsy, obstructive sleep apnea, and shift work sleep disorder. They are eugeroics, often known as wakefulness-promoting agents, a class of medications.

The active component is the primary distinction between armodafinil and modafinil. As one of the two stereoisomers (chemical compounds with a particular arrangement of atoms) that make up the modafinil molecule, armodafinil is the active enantiomer of modafinil. While armodafinil is a pure version of the R-enantiomer of modafinil, modafinil is a mixture of both enantiomers.

Although the precise mechanism of action of armodafinil and modafinil is not fully understood, it is believed that they function by preventing the reuptake of dopamine and norepinephrine in the brain, which raises the levels of these neurotransmitters that are available for transmission between neurons. As a result, the brain’s wakefulness-regulating areas become more active, which boosts alertness and attentiveness.

Several clinical studies have compared the efficiency and security of armodafinil and modafinil. According to these research, these drugs are useful for treating narcolepsy and other sleep disorders in patients by increasing wakefulness and decreasing excessive drowsiness. Armodafinil, compared to modafinil, may have a longer duration of action and may be more successful in treating excessive sleepiness, according to some research.

A Bottle of Nuvigil

Armodafinil Scientific Findings?

Some of the main scientific findings on armodafinil are as follows:

  1. Armodafinil works well for adults with narcolepsy, obstructive sleep apnea, and shift work sleep disorder to increase wakefulness and decrease excessive drowsiness. Armodafinil dramatically improves alertness measures like the Epworth Drowsiness Scale and lessens the frequency and severity of excessive sleepiness in these situations, according to numerous clinical investigations.
  2. Most people tolerate modafinil well and it has an excellent safety profile. Armodafinil’s most frequent adverse effects include headache, nausea, dizziness, and nervousness. These effects are typically mild and go away on their own. Although they are uncommon, more severe side effects can include chest pain, breathing problems, and skin rashes.
  3. Compared to other stimulant drugs, armodafinil may have a decreased risk of abuse and dependence. Armodafinil may be less likely to be abused and become dependent on than other stimulant drugs like amphetamines, according to some studies. To completely comprehend the risk of armodafinil abuse and dependence, more research is necessary.
  4. Compared to modafinil, armodafinil may have a more prolonged period of effect. Due to its longer half-life, armodafinil may have a longer duration of action than modafinil, according to certain research. Armodafinil may be able to lessen excessive daytime sleepiness as a result of this.


It is crucial to keep in mind that additional research is required to completely comprehend the effects and potential hazards of this medication, and that the key scientific findings on armodafinil listed here are just a small sample. It is advised to consult a healthcare professional if you have any queries concerning the administration of armodafinil.

Armodafinil Resources

Armodafinil can be found in a variety of online places, including:

  1. Information about the use, dosage, and possible adverse effects of armodafinil can be found online in a variety of different drug information resources. Armodafinil’s package leaflet as well as drug information tools like the Micromedex Drug Information app may be among these sources.
  2. Professional associations: A number of associations, including the American Academy of Sleep Medicine, have online materials on the use of armodafinil and other sleep disorders. Guidelines, suggestions for clinical practise, and teaching materials are a few examples of these tools.
  3. Clinical trial databases: Clinical trials are human-centered research projects intended to assess the efficacy and safety of novel interventions or treatments. Online access to a database of armodafinil and other sleep disorder clinical studies is provided by the National Institute of Neurological Disorders and Stroke (NINDS). By going to the NINDS Clinical Trials website, you can look for clinical trials with armodafinil.
  4. Online forums for support: Online support groups are readily available for those who suffer from narcolepsy, obstructive sleep apnea, and other sleep disorders. These organisations could offer guidance and details on the use of armodafinil and other sleep disorders medications.


It is crucial to remember that before using internet resources as a source of information, it is crucial to thoroughly assess their quality and dependability. This may entail taking into account the information’s credibility and source, as well as any possible conflicts of interest or bias. It is advised that you see a healthcare professional if you have any concerns regarding the accuracy or dependability of a particular web source on armodafinil.