Proteomics

Protea offers mass spectrometry-based proteomics services to answer the most intriguing bioanalytical questions. Using your input, our experienced proteomics scientists will design a strategy that efficiently analyzes your sample of interest and provides you with data you need. Our state-of-the-art instrumentation including high-resolution exact mass, MS/MS and MSE technology as well as the most advanced triple quadrupole systems and software. Our expertise and resources give you access to the most common and the must advanced proteomics services.

Services are available for:

• Top-down proteomics
• Quantitative proteomics
• Biomarker identification
• Post-translational modification characterization
• Custom services

Whether your sample is in solution, in a gel, or in a biological matrix, Protea offers tools to facilitate your sample preparation and processing for direct analysis by mass spectrometry. We utilize an integrated approach to services, focused on upstream sample preparation, downstream mass spectrometric analysis, and project consultation.

Examples of Advanced Proteomics Services
Quantitative MS proteomics:

• MRM assay
• iTRAQ
• Specialized iTRAQ (Phospho-iTRAQ)
• Label Free Quantitation
• Amino acid composition and extinction coefficient
• LAESI® biomolecular quantitation services

Qualitative MS Proteomics

• Specialized PTM analysis
• N-Linked oligosaccharide mapping
• O-Linked oligosaccharide mapping
• Global proteome characterization
• Peptide mapping
• Assessment of the di-sulfide bridge patterns
• Intact protein analysis
• ETD
• Degradation studies
• Metabolite profiling/ID
• Amino acid composition and extinction coefficient
• LAESI biomolecular profiling services

Gel Based Services:

• 1D and 2D SDS PAGE
• Intact protein gel recovery and MS analysis