MS Imaging Resources

Histology Guided Mass Spectrometry Determines Proteomic Differences Associated with Carbon Nanotube Exposure in the Lung

Multi-walled carbon nanotubes (MWCNT) have tremendous industry application, however, their unique physicochemical properties may pose health risks after inhalation. For insight into the adverse mechanisms associated with MWCNT deposition in the lung, histology guided mass spectrometry profiling was used. In this approach, alveolar and terminal bronchiole regions were targeted to study proteomic differences that occur as the result of exposure to MWCNT, with and without visible deposition.





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