Research Laboratory
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- Mass Spec Imaging Services
- – LAESI-MSI
- – MALDI-MSI
- – Histology Guided Mass Spectrometry
- – Combined Imaging Services
- Bioanalytical Services
- – Biomarker Discovery
- – Biotherapeutic Characterization
- – Advanced Proteomics
- – Protein and Peptide Quantitation
- About Our Lab
- – Laboratory Infrastructure
- – Our Integrated Approach
- – What is Mass Spec Imaging?
- – Imaging Sample Types
- Case Studies and App Notes
- imageSIGHT Data Reporting
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MALDI-MSI
MALDI-MSI services from Protea provide high-resolution mass spec positioning data from your tissue samples of interest. MALDI-MSI is a more traditional approach for mass spec imaging workflows and offers a large body of validated protocols.
FEATURES:
SAMPLE TYPES:
MALDI-MSI- Spatial resolution: 60µm (Whole body @ 300µm)
- Typical data turnaround time: 2 weeks or less
- Sample preparation and cryosectioning available
SAMPLE TYPES:
- Tissue Sections
- Tissue section analysis (10mm x 10mm)
- Whole body tissue section analysis (typically 75mm x 25mm)
- Trypsin digestion and profiling (10mm x 10mm)
Tissue sections are mounted on standard MALDI plates and prepared using our proprietary UltraPure MALDI Matrices. We offer more than 10 different matrix chemistries for a variety of specific applications. Samples are analyzed using a Bruker ultrafleXtreme™ TOF/TOF mass spectrometer. Analysis is typically performed on samples with the target area of up to 10mm x 10mm at 60μm spatial resolution (or larger if analyzing larger samples, as discussed with customer). Standard data reports contain up to five contour plots of desired m/z of interest, as well as an average MS fingerprint of the entire sample. Further contour plots and MS/MS confirmation can also be performed at an additional cost.
…imaging the future of biology