About Our Lab

Proteomics Services:
- Top-down proteomics
- Quantitative proteomics
- Biomarker characterization
- Post-translational modification characterization
- Protein interaction studies
- Peptide mapping
- Total amino acid analysis
- Custom services
Drug Discovery Services:
- Combinatorial library hit identification
- Hit-to-lead assay development
- Lead optimization
- Assay development and screening
- Support for secondary lead compounds
Large Molecule Bioanalytical Services:
- Novel assay development and/or assay transfer
- GLP or Fit-for-Purpose (FFP) assay validation and sample analysis
- Quantitative analysis using:
- Signature peptides and MRM assays
- Immunoprecipitation and immunoaffinity capture
- Advanced chromatography techniques
Small Molecule Bioanalytical Services:
- PK Drug Discovery Support
- Metabolite ID (Predictive and Unknown) and stability
- Novel Method Development
- GLP Validation
- GLP Sample Assays from pilot studies to pre-clinical to Phase 3 trials
- Bioequivalence Studies
Instrumentation:
- Protea LAESI DP-1000 System
- Waters Synapt® G2-S HDMS + UPLC
- 2 x AB Sciex QTRAP® 5500 + Shimadzu HPLC
- 2 x AB Sciex API 4000™ + Shimadzu HPLC
- Hitachi L8900 Total Amino Acid Analyzer
All instruments are powered by uninterruptable power supplies, and are supported with a natural gas generator with automatic start-up for electrical back-up.
Software:
Biomolecular Imaging:
- ProteaPlot™
Molecular Quantitation
- Analyst (v. 1.5)
- Thermo Scientific Watson LIMS™
- MassLynx™ v. 4.1
- MultiQuant™
- MRMPilot™
Metabolite Identification:
- LightSight™
- MetaboLynx™ XS
Proteomics:
- Transform
- MaxEnt™ 1
- BiopharmaLynx™
- BioLynx®
- MarkerLynx™
- ProteinLynx Global SERVER™ (PLGS)
- ProteinPilotTM
- Protein Center
Statistical Analysis:
- Phoenix® WinNonlin®
…innovations for bioanalytics